Ohmori T, Uraga N, Komi K, Tabei R, Matsuda R, Kodama T, Iwahashi K
Second Department of Pathology, Ehime University School of Medicine, Japan.
Acta Pathol Jpn. 1990 Aug;40(8):596-601. doi: 10.1111/j.1440-1827.1990.tb01605.x.
A case of primary gastric plasmacytoma expressing various surface and cytoplasmic antigens is reported. With the use of formalin-fixed and deparaffinized sections, 13 different antibodies were applied. Neoplastic plasma cells revealed monoclonal IgG and kappa light chain in the cytoplasm, and expressed epithelial membrane antigen, Ki 67 antigen, cytokeratin, CD 22 antigen, interleukin-2 receptor antigen, leukocyte common antigen and Ki-1 (CD 30) antigen. However, tumor cells were devoid of HLA-DR antigen. These data suggest that the neoplastic plasma cells are at the plasmoblastic stage of maturation and express various surface and cytoplasmic phenotypes.
报告了一例表达多种表面和细胞质抗原的原发性胃浆细胞瘤。使用福尔马林固定、脱石蜡切片，应用了13种不同抗体。肿瘤性浆细胞在细胞质中显示单克隆IgG和κ轻链，并表达上皮膜抗原、Ki 67抗原、细胞角蛋白、CD 22抗原、白细胞介素-2受体抗原、白细胞共同抗原和Ki-1（CD 30）抗原。然而，肿瘤细胞缺乏HLA-DR抗原。这些数据表明，肿瘤性浆细胞处于成熟的浆母细胞阶段，并表达多种表面和细胞质表型。
