Möller P, Matthaei-Maurer D U, Moldenhauer G
Institute of Pathology, Heidelberg University, West Germany.
Am J Clin Pathol. 1989 Jan;91(1):18-23. doi: 10.1093/ajcp/91.1.18.
With the use of frozen sections, 24 different monoclonal antibodies (MoAbs), and an indirect peroxidase technique, the antigenic profile of a well-differentiated primary gastric plasmacytoma was obtained. Corresponding to the normal plasma cell, tumor cells were devoid of HLA-D products and B-cell-restricted differentiation antigens CD19, CD20, CD21, CD22, and CD23 while expressing plasma cell-associated CD24 and CD38 molecules and IgA/lambda. The plasmacytoma furthermore reacted with CD30(Ki-1), a reactivity that for this tumor type has not been reported before. Subsequently, normal gastric mucosae affected by all degrees of chronic gastritis were examined. On the basis of serial sections, 5-15% of CD38(OKT10) reactive mucosal plasma cells were observed to also react with CD30(Ki-1). The authors conclude that the CD30 antigen is not only an activation antigen but is also expressed on a subset of terminally differentiated plasma cells.
运用冷冻切片、24种不同的单克隆抗体（MoAbs）以及间接过氧化物酶技术，获得了一例高分化原发性胃浆细胞瘤的抗原谱。与正常浆细胞一致，肿瘤细胞缺乏HLA-D产物以及B细胞限制性分化抗原CD19、CD20、CD21、CD22和CD23，同时表达浆细胞相关的CD24和CD38分子以及IgA/λ。该浆细胞瘤还与CD30（Ki-1）发生反应，这种反应此前尚未见针对该肿瘤类型的报道。随后，对不同程度慢性胃炎累及的正常胃黏膜进行了检查。基于连续切片观察到，5%至15%的CD38（OKT10）反应性黏膜浆细胞也与CD30（Ki-1）发生反应。作者得出结论，CD30抗原不仅是一种激活抗原，而且也在终末分化浆细胞的一个亚群上表达。
