小鼠痒病的化学预防
Chemoprophylaxis of scrapie in mice.
作者信息
Diringer H, Ehlers B
机构信息
Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Germany.
出版信息
J Gen Virol. 1991 Feb;72 ( Pt 2):457-60. doi: 10.1099/0022-1317-72-2-457.
PMID:1704414
Abstract
Three applications of the polyanion pentosanpolysulphate about 2 months before infection of mice with scrapie completely protected animals infected with up to 100 LD50, and considerably prolonged the lifespan of those infected with 100 to 10,000 LD50. The clinical diagnosis was confirmed by immunoblot analysis for the protein of scrapie-associated fibrils.
摘要
在用羊瘙痒病感染小鼠前约2个月，给予聚阴离子戊聚糖多硫酸盐三次，可使感染高达100个半数致死量（LD50）的动物得到完全保护，并显著延长感染100至10,000个LD50的动物的寿命。通过对瘙痒病相关纤维蛋白进行免疫印迹分析，证实了临床诊断。
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