弱突变体可推动大肠杆菌中氟喹诺酮耐药性的演变。
Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.
作者信息
Orlén Hanna, Hughes Diarmaid
机构信息
Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Uppsala, Sweden.
出版信息
Antimicrob Agents Chemother. 2006 Oct;50(10):3454-6. doi: 10.1128/AAC.00783-06.
Abstract
Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.
摘要
弱突变体在大肠杆菌临床分离株中很常见。我们发现，相对突变率与“氟喹诺酮耐药性的进化能力”在3个数量级上呈幂律斜率为1.2的关系。因此，即使是弱突变体在选择压力下也能推动氟喹诺酮耐药性的进化。
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本文引用的文献
1
Evolution of mutation rates in bacteria.
Mol Microbiol. 2006 May;60(4):820-7. doi: 10.1111/j.1365-2958.2006.05150.x.
2
qnrB, another plasmid-mediated gene for quinolone resistance.
Antimicrob Agents Chemother. 2006 Apr;50(4):1178-82. doi: 10.1128/AAC.50.4.1178-1182.2006.
3
Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli.
Genetics. 2005 Oct;171(2):825-7. doi: 10.1534/genetics.105.045526. Epub 2005 Jun 18.
4
Transcription promotes guanine to thymine mutations in the non-transcribed strand of an Escherichia coli gene.
DNA Repair (Amst). 2005 Jul 12;4(7):806-13. doi: 10.1016/j.dnarep.2005.04.017.
5
Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.
Int J Antimicrob Agents. 2005 May;25(5):358-73. doi: 10.1016/j.ijantimicag.2005.02.006.
6
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.
Antimicrob Agents Chemother. 2005 Feb;49(2):801-3. doi: 10.1128/AAC.49.2.801-803.2005.
7
Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo.
DNA Repair (Amst). 2004 Dec 2;3(12):1579-90. doi: 10.1016/j.dnarep.2004.06.012.
8
Polymorphic mutation frequencies in Escherichia coli: emergence of weak mutators in clinical isolates.
J Bacteriol. 2004 Aug;186(16):5538-42. doi: 10.1128/JB.186.16.5538-5542.2004.
9
Specificity of spontaneous mutations induced in mutA mutator cells.
Mutat Res. 2004 Apr 14;548(1-2):9-18. doi: 10.1016/j.mrfmmm.2003.12.005.
10
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
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