从福氏志贺菌2b型的一个可转移质粒中克隆一种新型喹诺酮耐药基因。
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.
作者信息
Hata Mami, Suzuki Masahiro, Matsumoto Masakado, Takahashi Masao, Sato Katsuhiko, Ibe Shiro, Sakae Kenji
机构信息
Department of Microbiology, Aichi Prefectural Institute of Public Health, 7-6 Nagare, Tsujimachi, Kita-ku, Nagoya, Aichi 462-8576, Japan.
出版信息
Antimicrob Agents Chemother. 2005 Feb;49(2):801-3. doi: 10.1128/AAC.49.2.801-803.2005.
Abstract
A novel gene for quinolone resistance was cloned from a transferable plasmid carried by a clinical isolate of Shigella flexneri 2b that was resistant to fluoroquinolones. The plasmid conferred low-level resistance to quinolones on Escherichia coli HB101. The protein encoded by the gene showed 59% amino acid identity with Qnr.
摘要
从一株对氟喹诺酮耐药的福氏志贺菌2b临床分离株携带的可转移质粒中克隆出一个新的喹诺酮耐药基因。该质粒赋予大肠杆菌HB101低水平的喹诺酮耐药性。该基因编码的蛋白质与Qnr的氨基酸同一性为59%。
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