蛋白质 O-甘露糖基转移酶同工型调节白色念珠菌中的生物膜形成。
Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.
作者信息
Peltroche-Llacsahuanga Heidrun, Goyard Sophie, d'Enfert Christophe, Prill Stephan K-H, Ernst Joachim F
机构信息
Institut für Medizinische Mikrobiologie, RWTH Aachen, Germany.
出版信息
Antimicrob Agents Chemother. 2006 Oct;50(10):3488-91. doi: 10.1128/AAC.00606-06.
Abstract
Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.
摘要
蛋白质甘露糖基转移酶（Pmt）的五种同工型在白色念珠菌中对分泌蛋白进行O-甘露糖基化修饰。pmt突变体在静态和流通系统中于塑料上形成生物膜时存在不同程度的缺陷，并且一种Pmt抑制剂可阻断生物膜形成的早期阶段。从概念上讲，抑制Pmt可能会阻止真菌病原体的表面锚定和生物膜依赖性抗性。
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