Sheppard Donald C, Graybill John R, Najvar Laura K, Chiang Lisa Y, Doedt Thomas, Kirkpatrick William R, Bocanegra Rosie, Vallor Ana C, Patterson Thomas F, Filler Scott G
McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada.
Antimicrob Agents Chemother. 2006 Oct;50(10):3501-3. doi: 10.1128/AAC.00787-06.
Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.
评估侵袭性曲霉病的新型治疗药物需要在不同实验室之间具有可重复性的动物模型。因此,我们在两个独立的实验室中评估了一种气溶胶感染小鼠模型,发现其在实验室内部和实验室之间的生存率、随时间变化的真菌负荷以及脂质体两性霉素B的疗效都具有很高的可重复性。