Chandra Amar K, Singh L Hemchandra, Tripathy Smritiratan, Debnath Arijit, Khanam Jasmina
Department of Physiology, University College of Science and Technology, University of Calcutta, Kolkata, India.
Indian J Pediatr. 2006 Sep;73(9):795-8. doi: 10.1007/BF02790388.
To assess the iodine nutritional status of school children in selected areas of Imphal West District of Manipur where endemic goitre and associated iodine deficiency disorders (IDD) are prevalent in the post-salt iodization period.
A total of 961 school children in the age group 6-12 yrs of both sexes were clinically examined for goiter from three study areas- one from rural block and two from urban areas. One hundred twenty urine samples were analysed for iodine and thiocyanate respectively. One hundred and five edible salt samples were also collected from the households to evaluate the iodine content. Drinking water samples from different sources were collected and iodine level was analysed to study the bioavailability of iodine in the region.
The total goiter rate was 34.96% (Grade 1- 32.15%; Grade 2- 2.81%) showing that IDD is a severe public health problem. The median urinary iodine levels in the studied areas were in the ranges from 12.5-17.5 microg/dl indicating no biochemical iodine deficiency in the region. Mean urinary thiocyanate level was 0.839+/-0.33 mg/dl showing that the people consume sufficient foods containing thiocyanate precursors. About 82% salt samples had iodine level more than 30 ppm and the iodine content in salt samples less than 15 ppm was only about 3% indicating the salt samples at house hold contain adequate iodine.
Iodine content in drinking water samples ranged from 1.8-2.6 microg/l showing that the studied region is environmentally iodine deficient. Inspite of the consumption of adequate iodine, the existing goiter prevalence among school children during post salt iodization phase ensures that environmental factors other than iodine deficiency may have the possible role in the persistence of endemic goiter in the population. The role of thiocyanate in this regard may not be ruled out.
评估在曼尼普尔邦英帕尔西区选定地区学龄儿童的碘营养状况，该地区在食盐碘化后地方性甲状腺肿及相关碘缺乏病（IDD）仍然普遍存在。
对来自三个研究地区（一个来自农村街区，两个来自城市地区）的961名6至12岁的学龄儿童进行甲状腺肿临床检查。分别对120份尿样进行碘和硫氰酸盐分析。还从家庭中收集了105份食用盐样本以评估碘含量。收集不同来源的饮用水样本并分析碘含量，以研究该地区碘的生物利用度。
甲状腺肿总患病率为34.96%（1级为32.15%；2级为2.81%），表明碘缺乏病是一个严重的公共卫生问题。研究地区尿碘中位数水平在12.5 - 17.5微克/分升范围内，表明该地区不存在生化碘缺乏。尿硫氰酸盐平均水平为0.839±0.33毫克/分升，表明人们摄入了足够的含硫氰酸盐前体的食物。约82%的盐样本碘含量超过30 ppm，碘含量低于15 ppm的盐样本仅约3%，表明家庭中的盐样本碘含量充足。
饮用水样本中的碘含量在1.8 - 2.6微克/升范围内，表明研究地区环境缺碘。尽管摄入了足够的碘，但在食盐碘化后阶段学龄儿童中现有的甲状腺肿患病率表明，除碘缺乏外的环境因素可能在人群中地方性甲状腺肿的持续存在中发挥作用。在这方面硫氰酸盐的作用不能排除。
Zotero 插件