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印度南部一家三级护理医院的甲状腺肿大与碘营养状况

Thyromegaly and iodine nutritional status in a tertiary care hospital in South India.

作者信息

Chandrasekaran Maharajan, Ramadevi Kanakasabapathi

机构信息

Department of Endocrine Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.

出版信息

Indian J Endocrinol Metab. 2013 Mar;17(2):260-4. doi: 10.4103/2230-8210.109701.

DOI:10.4103/2230-8210.109701
PMID:23776899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3683201/
Abstract

AIM AND OBJECTIVES

  1. To assess the iodine nutritional status in patients with goiter by measuring urinary iodine excretion. 2. To compare the iodine nutritional status with the thyroid function and correlate with the type of thyroid disease.

STUDY DESIGN

Case control study.

MATERIALS AND METHODS

Three hundred patients with goiter and one hundred euthyroid healthy non-goitrous volunteers were included in this study.

RESULTS AND CONCLUSIONS

All patients had elevated urinary iodine suggesting excess iodine intake and absence of iodine deficiency. Complications known to be associated with excess iodine, viz., benign goiter (35%), iodine-induced hyperthyroidism or thyrotoxicosis (34%), thyroiditis (16%) and cancer of thyroid (15%) have been observed in this study. Therefore, continued supplementation of edible salt fortified with iodine should be monitored carefully, and supplementation programs should be tailored to the particular region.

摘要

目的与目标

  1. 通过测量尿碘排泄评估甲状腺肿患者的碘营养状况。2. 将碘营养状况与甲状腺功能进行比较，并与甲状腺疾病类型相关联。

研究设计

病例对照研究。

材料与方法

本研究纳入了300例甲状腺肿患者和100例甲状腺功能正常的非甲状腺肿健康志愿者。

结果与结论

所有患者尿碘升高，提示碘摄入过量且不存在碘缺乏。本研究中观察到了已知与碘过量相关的并发症，即良性甲状腺肿（35%）、碘致甲状腺功能亢进或甲状腺毒症（34%）、甲状腺炎（16%）和甲状腺癌（15%）。因此，应仔细监测持续补充加碘食用盐的情况，并且补充方案应根据特定地区进行调整。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820b/3683201/30b2569b0f32/IJEM-17-260-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820b/3683201/b081591184bf/IJEM-17-260-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820b/3683201/30b2569b0f32/IJEM-17-260-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820b/3683201/b081591184bf/IJEM-17-260-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/820b/3683201/30b2569b0f32/IJEM-17-260-g007.jpg

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本文引用的文献

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Continuation of high goiter prevalence in regions with successful salt iodization program.在成功实施食盐碘化计划的地区，高甲状腺肿患病率持续存在。
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Residual goitre in the postiodization phase: iodine status, thiocyanate exposure and autoimmunity.碘盐普及阶段的残余甲状腺肿：碘状态、硫氰酸盐暴露与自身免疫
Clin Endocrinol (Oxf). 2003 Dec;59(6):672-81. doi: 10.1046/j.1365-2265.2003.01895.x.
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"Endemic coast goitre" in Hokkaido, Japan.
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