印度北方邦东部锡德哈特纳格尔区某些地区地方性甲状腺肿持续存在的病因
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India.
作者信息
Chandra A K, Bhattacharjee A, Malik T, Ghosh S
机构信息
Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University College of Science and Technology, University of Calcutta, West Bengal, India.
出版信息
J Pediatr Endocrinol Metab. 2009 Apr;22(4):317-25. doi: 10.1515/jpem.2009.22.4.317.
AIM
To assess the prevalence of goiter, state of iodine nutrition of the population, consumption pattern of common goitrogenic food, and distribution of iodine through edible salt in selected CD Blocks of Siddharthnagar district in Eastern Uttar Pradesh.
METHODS
Goiter survey among 1,862 school children, aged 6-12 years, of both sexes, and analysis of iodine (I) and thiocyanate (SCN) in 240 urine samples, and iodine content in 210 edible salt samples collected from the selected study areas.
RESULTS
The prevalence of goiter was 26.3% (grade 1: 23.2%; grade 2: 3.1%). Median urinary iodine level was 6.0 microg/dl, and 42% had concentration < 5 microg/dl. Mean (SD) urinary SCN was 0.75 (0.4) mg/dl. Only17.1% of salt samples had iodine level > 15 ppm; 82.9% had < 15 ppm.
CONCLUSION
Consumption of inadequately iodized salt and cyanogenic plant foods containing goitrogenic/anti-thyroidal substances by the people of the studied region are possible reasons for the persistence of goiter during the post salt iodination phase.
目的
评估印度北方邦东部锡德哈特纳加尔区选定社区发展街区中甲状腺肿的患病率、人群碘营养状况、常见致甲状腺肿食物的消费模式以及食用盐中的碘分布情况。
方法
对1862名6至12岁的学龄儿童（男女均有）进行甲状腺肿调查，分析从选定研究区域收集的240份尿液样本中的碘（I）和硫氰酸盐（SCN），以及210份食用盐样本中的碘含量。
结果
甲状腺肿患病率为26.3%（1级：23.2%；2级：3.1%）。尿碘中位数水平为6.0微克/分升，42%的人尿碘浓度<5微克/分升。尿SCN的平均（标准差）值为0.75（0.4）毫克/分升。只有17.1%的盐样本碘含量>15 ppm；82.9%的盐样本碘含量<15 ppm。
结论
在碘盐碘化阶段之后，甲状腺肿持续存在的可能原因是研究区域的人们食用了碘强化不足的盐以及含有致甲状腺肿/抗甲状腺物质的含氰植物性食物。
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