Nadeau Joseph H, Topol Eric J
Department of Genetics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA.
Nat Genet. 2006 Oct;38(10):1095-8. doi: 10.1038/ng1006-1095.
Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.
最近几种备受瞩目的药物的使用经验表明，开发有效且安全的治疗方法面临巨大挑战。与疾病遗传学这一流行范式相辅相成的方法是基于遗传因素，这些因素可降低那些具有疾病遗传易感性的个体中疾病的发病率和严重程度。我们建议对高危个体中的修饰基因和保护性等位基因进行专门检测，并基于健康遗传学研究治疗方法的疗效。
