从“魔弹”到“特制散弹装药”：新遗传学与个体化药物治疗的必要性。

From "magic bullet" to "specially engineered shotgun loads": the new genetics and the need for individualized pharmacotherapy.

作者信息

Erickson R P

机构信息

Angel Charity for Children-Wings for Genetic Research, Steele Memorial Children's Research Center, Department of Pediatrics, University of Arizona College of Medicine, Tucson 85724-5073, USA.

出版信息

Bioessays. 1998 Aug;20(8):683-5. doi: 10.1002/(SICI)1521-1878(199808)20:8<683::AID-BIES12>3.0.CO;2-V.

DOI:10.1002/(SICI)1521-1878(199808)20:8<683::AID-BIES12>3.0.CO;2-V

PMID:9780843

Abstract

Steady progress in the identification of human pharmacogenetic variants and new discoveries of disease susceptibility genes makes the old notion of one disease/one drug untenable. Advances in the ability to rapidly identify these variants, when coupled with appropriate drug delivery systems, should revolutionize pharmacotherapy.

摘要

人类药物遗传学变异识别方面的稳步进展以及疾病易感基因的新发现，使得“一种疾病/一种药物”的旧观念站不住脚。快速识别这些变异的能力取得进展，再加上合适的药物递送系统，有望彻底变革药物治疗。