Narayanaswamy S
Rajal Biotechnologies, Fremont, CA, USA.
Indian Pacing Electrophysiol J. 2002 Apr 1;2(2):50-6.
Over the past decade, significant advances were made in the research, diagnosis, and treatment of cardiovascular diseases. Such progress was in every sphere of cardiology that includes non-invasive, minimally invasive, and invasive technologies. Interpretive electrocardiography, cardiac pacemakers, cardiac stents, and angioplasty are some areas where the progress has been significant. Non-invasive methods of diagnosis of cardiac disorders involve digital recording of cardiac signals at the body surface (chest) and subsequent computerized analysis. Such methods and instruments provide a vital first step to the diagnosis of the heart without involving surgical procedures. One such non-invasive field is High Resolution Electrocardiography (HRECG). A high-resolution electrocardiogram detects very low amplitude signals in the ventricles called 'Late Potentials' in patients with abnormal heart conditions. A standard electrocardiogram cannot detect these signals. The presence of late potentials is widely accepted to have prognostic significance in patients after Acute Myocardial Infarction (AMI) High Resolution Electrocardiography enhances the diagnostic capabilities of ECGs. This article describes the principles involved in HRECG and the techniques that are employed to derive such superior diagnostic capabilities. The use of these techniques may lead to more discoveries in the causes of cardiac disorders and improved drug discoveries to combat such conditions.
在过去十年中，心血管疾病的研究、诊断和治疗取得了重大进展。这种进展体现在心脏病学的各个领域，包括非侵入性、微创和侵入性技术。解释性心电图、心脏起搏器、心脏支架和血管成形术等领域都取得了显著进展。心脏疾病的非侵入性诊断方法包括在体表（胸部）对心脏信号进行数字记录，随后进行计算机分析。这些方法和仪器为不涉及外科手术的心脏诊断提供了至关重要的第一步。高分辨率心电图（HRECG）就是这样一个非侵入性领域。高分辨率心电图能检测出心脏异常患者心室中极低振幅的信号，即所谓的“晚电位”。标准心电图无法检测到这些信号。急性心肌梗死（AMI）患者中晚电位的存在被广泛认为具有预后意义。高分辨率心电图增强了心电图的诊断能力。本文描述了高分辨率心电图所涉及的原理以及用于获得这种卓越诊断能力的技术。这些技术的应用可能会在心脏疾病病因方面带来更多发现，并改善对抗此类疾病的药物研发。
