Santeufemia Davide Adriano, Piredda Gianfranca, Fadda Giovanni Maria, Cossu Rocca Paolo, Costantino Salvatore, Sanna Giovanni, Sarobba Maria Giuseppa, Pinna Maria Antonietta, Putzu Carlo, Farris Antonio
University of Sassari, Viale San Pietro 8, 07100 Sassari, Sardinia, Italy.
World J Gastroenterol. 2006 Sep 14;12(34):5565-8. doi: 10.3748/wjg.v12.i34.5565.
Esophageal cancer (EC) is a highly lethal disease. Approximately 50% of patients present with metastatic EC and most patients with localized EC will have local recurrence or develop metastases, despite potentially curative local therapy. The most common sites of distant recurrence are represented by lung, liver and bone while brain and breast metastases are rare. Usually patients with advanced disease are not treated aggressively and their median survival is six months. We report a woman patient who developed breast and brain metastases after curative surgery. We treated her with a highly aggressive chemotherapeutic and surgical combination resulting in a complete remission of the disease even after 11-year follow-up. We think that in super selected patients with more than one metastasis, when functional status is good and metastases are technically resectable, a surgical excision may be considered as a salvage option and chemotherapy should be delivered to allow a systemic control.
食管癌（EC）是一种致死率很高的疾病。约50%的患者就诊时已出现转移性食管癌，尽管接受了可能治愈性的局部治疗，但大多数局限性食管癌患者仍会出现局部复发或发生转移。远处复发最常见的部位是肺、肝和骨，而脑和乳腺转移则较为罕见。通常，晚期疾病患者不会接受积极治疗，其平均生存期为6个月。我们报告了一名女性患者，她在接受根治性手术后出现了乳腺和脑转移。我们对她采用了高度积极的化疗与手术联合治疗，即使在11年的随访后，疾病仍完全缓解。我们认为，在经过超选择的有多处转移的患者中，当功能状态良好且转移灶在技术上可切除时，手术切除可被视为一种挽救性选择，并且应进行化疗以实现全身控制。
