Albertsson Maria
Department of Oncology, Malmö University Hospital, Sweden.
Acta Oncol. 2002;41(2):118-23. doi: 10.1080/028418602753669472.
Esophageal cancer is a disease with a poor prognosis and high biological aggressiveness. The disease used to be considered a mainly local problem, and palliative care with relief of dysphagia was the goal for most of those concerned with the disease. When surgical techniques were improved and parallel progress was made in intensive care and postoperative care, some patients could be cured of the disease. The development of pre- or postoperative radiotherapy also improved local control. Partly because of the interest that began to be focused on improving survival for this diagnostic group, chemotherapy combined with radiotherapy has been incorporated into the therapeutic arsenal. The aim of this review is to shed light on current treatment principles for esophageal cancer. However, treatment results from studies utilizing combination chemotherapy given concurrently with radiotherapy support the conclusion that well-designed randomized trials with long-term follow-ups should be performed.
食管癌是一种预后较差且具有高生物侵袭性的疾病。该疾病过去被认为主要是局部问题，对大多数关注该疾病的人来说，缓解吞咽困难的姑息治疗是目标。当手术技术得到改进且重症监护和术后护理也取得相应进展时，一些患者能够治愈该疾病。术前或术后放疗的发展也改善了局部控制。部分由于开始关注提高这一诊断组的生存率，化疗联合放疗已被纳入治疗手段。本综述的目的是阐明目前食管癌的治疗原则。然而，同时进行化疗联合放疗的研究结果支持这样的结论，即应该开展设计良好且进行长期随访的随机试验。
