糖尿病患者的上消化道功能与血糖控制
Upper gastrointestinal function and glycemic control in diabetes mellitus.
作者信息
Chaikomin Reawika, Rayner Christopher K, Jones Karen-L, Horowitz Michael
机构信息
Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
出版信息
World J Gastroenterol. 2006 Sep 21;12(35):5611-21. doi: 10.3748/wjg.v12.i35.5611.
Abstract
Recent evidence has highlighted the impact of glycemic control on the incidence and progression of diabetic micro- and macrovascular complications, and on cardiovascular risk in the non-diabetic population. Postprandial blood glucose concentrations make a major contribution to overall glycemic control, and are determined in part by upper gastrointestinal function. Conversely, poor glycemic control has an acute, reversible effect on gastrointestinal motility. Insights into the mechanisms by which the gut contributes to glycemia have given rise to a number of novel dietary and pharmacological strategies designed to lower postprandial blood glucose concentrations.
摘要
最近的证据凸显了血糖控制对糖尿病微血管和大血管并发症的发生及进展，以及对非糖尿病人群心血管风险的影响。餐后血糖浓度对整体血糖控制有重要作用，且部分由上消化道功能决定。相反，血糖控制不佳对胃肠动力有急性、可逆的影响。对肠道影响血糖机制的深入了解催生了一些旨在降低餐后血糖浓度的新型饮食和药物策略。
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