Liang Y R, Cheng R X, Shen M, Guo Y X, Su X S
Department of Pathology, Human Medical University, Changsha.
Chin Med J (Engl). 1990 Aug;103(8):623-8.
64 cases of chronic active hepatitis (CAH) and 84 cases of non-CAH liver diseases were studied with keratin stain. The capillary-like bile ductules (CLBD) were proliferating and their morphology was identical to that with Type V collagen stain reported before. CLBD proliferation were more marked in CAH than in other liver diseases, and it was considered to be one of the characteristics of CAH and could be used for differential diagnosis. The ultrastructure of CLBD was specific in morphology. The HBV-DNA in CLBD shown by the technique of in situ hybridization suggested that HBV might infect the cells of CLBD.
对64例慢性活动性肝炎（CAH）和84例非CAH肝病患者进行了角蛋白染色研究。毛细血管样胆小管（CLBD）增生，其形态与之前报道的Ⅴ型胶原染色所见相同。CLBD增生在CAH中比在其他肝病中更明显，被认为是CAH的特征之一，可用于鉴别诊断。CLBD的超微结构在形态上具有特异性。原位杂交技术显示CLBD中有HBV-DNA，提示HBV可能感染CLBD细胞。
