Liang Y R
Zhonghua Bing Li Xue Za Zhi. 1989 Mar;18(1):5-7.
64 cases of chronic active hepatitis (CAH) and 84 cases of other chronic liver diseases were studied with keratin antibody immunohistochemistry. Proliferation of capillary-like bile ductules (CLBD) was more remarkable in the former cases than that in the latter cases with positive keratin reaction in the cytoplasm. Therefore, proliferation of CLBD was considered to be a characteristic lesion of CAH, which might be used as one of the criteria for differential diagnosis of CAH. This paper also reports the ultrastructural appearance of CLBD in detail and the result of HBV DNA in situ hybridization for CLBD, suggesting that HBV might infect CLBD.
应用角蛋白抗体免疫组织化学方法对64例慢性活动性肝炎（CAH）和84例其他慢性肝病进行了研究。前一组病例中，细胞质呈角蛋白反应阳性的毛细血管样胆小管（CLBD）增生比后一组病例更为显著。因此，CLBD增生被认为是CAH的特征性病变，可作为CAH鉴别诊断的标准之一。本文还详细报道了CLBD的超微结构表现以及CLBD的乙肝病毒DNA原位杂交结果，提示乙肝病毒可能感染CLBD。
