Allmyr Mats, Adolfsson-Erici Margaretha, McLachlan Michael S, Sandborgh-Englund Gunilla
Institute of Odontology, Karolinska Institutet, PO Box 4064, SE-141 04 Huddinge, Sweden.
Sci Total Environ. 2006 Dec 15;372(1):87-93. doi: 10.1016/j.scitotenv.2006.08.007. Epub 2006 Sep 26.
The bactericide triclosan is commonly used in e.g. plastics, textiles and health care products. In vitro studies on rat and human biological systems indicate that triclosan might exert adverse effects in humans. Triclosan has previously been found in human plasma and milk, but neither the primary source of human exposure nor the efficiency of triclosan transfer to human milk is known. In this study, plasma and milk were sampled from 36 mothers and analyzed for triclosan. Scrutinization of the women's personal care products revealed that nine of the mothers used toothpaste, deodorant or soap containing triclosan. Triclosan and/or its metabolites were omnipresent in the analyzed plasma and milk. The concentrations were higher in both plasma and milk from the mothers who used personal care products containing triclosan than in the mothers who did not. This demonstrated that personal care products containing triclosan were the dominant, but not the only, source of systemic exposure to triclosan. The concentrations were significantly higher in plasma than in milk, indicating that infant exposure to triclosan via breast milk is much less than the dose in the mother.
杀菌剂三氯生常用于塑料制品、纺织品和保健产品等。对大鼠和人类生物系统的体外研究表明，三氯生可能会对人类产生不良影响。此前在人体血浆和乳汁中发现过三氯生，但人类接触三氯生的主要来源以及三氯生向人乳转移的效率均未知。在本研究中，采集了36位母亲的血浆和乳汁样本，并对其中的三氯生进行分析。仔细检查这些女性的个人护理产品后发现，其中9位母亲使用了含三氯生的牙膏、除臭剂或肥皂。在所分析的血浆和乳汁中，三氯生及其代谢产物普遍存在。使用含三氯生个人护理产品的母亲，其血浆和乳汁中的三氯生浓度均高于未使用此类产品的母亲。这表明含三氯生的个人护理产品是三氯生全身暴露的主要来源，但并非唯一来源。血浆中的三氯生浓度显著高于乳汁中的浓度，这表明婴儿通过母乳接触到的三氯生剂量远低于母亲体内的剂量。
