分光光度法测定个人护理产品中的三氯生

Spectrophotometric determination of triclosan in personal care products.

作者信息

Lu Huihui, Ma Hongbing, Tao Guanhong

机构信息

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China.

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2009 Sep 1;73(5):854-7. doi: 10.1016/j.saa.2009.04.007. Epub 2009 Apr 23.

DOI:10.1016/j.saa.2009.04.007

PMID:19451017

Abstract

A spectrophotometric method for the determination of triclosan in personal care products was proposed. It was based on the reaction of sodium nitrite with p-sulfanilic acid in an acidic medium to form diazonium ion, with which triclosan further formed an azo compound in an alkaline medium. The resulting yellow colored product has a maximum absorption at 452 nm. A good linear relationship (r=0.9999) was obtained in the range of 0-30 mg L(-1) triclosan. A detection limit of 0.079 gL(-1) was achieved and the relative standard deviation was 0.24% (n=11) at 14 mg L(-1) triclosan. The proposed method has been applied to the analyses of triclosan in several personal care products and the results were in good agreement with those obtained by high-performance liquid chromatography.

摘要

提出了一种用于测定个人护理产品中三氯生的分光光度法。该方法基于亚硝酸钠与对氨基苯磺酸在酸性介质中反应形成重氮离子，三氯生在碱性介质中与重氮离子进一步形成偶氮化合物。生成的黄色产物在452nm处有最大吸收。在三氯生浓度为0 - 30mg L(-1)范围内获得了良好的线性关系（r = 0.9999）。检测限为0.079gL(-1)，在三氯生浓度为14mg L(-1)时相对标准偏差为0.24%（n = 11）。所提出的方法已应用于几种个人护理产品中三氯生的分析，结果与高效液相色谱法获得的结果吻合良好。