Mosavi-Jarrahi Alireza, Moini Mehdi, Mohagheghi Mohammad-Aali, Alebouyeh Mardawich, Yazdizadeh Bahareh, Shahabian Akbar, Nahvijo Azin, Alizadeh Reza
Department of Social Medicine, Medical School, Shaheed Beheshti University of Medical Sciences, P.O. Box 15875-4194, Tehran, Islamic Republic of Iran.
Int J Hyg Environ Health. 2007 Mar;210(2):113-9. doi: 10.1016/j.ijheh.2006.08.005. Epub 2006 Sep 27.
The aim of this study was both to map the childhood cancer incidence in the districts of Tehran metropolitan area and to explore possible clustering of cancer cases in the diverse environments of this area. All incidence cases of childhood cancers (age group under 15 years) belonging to the 22 districts of Tehran metropolis and occurring during the period of 1998 till 2002 were ascertained from three sources. Each case's place of residency was geo-referenced. The scan statistics cluster detecting technique was used to evaluate clustering of cases throughout Tehran. The overall incidence rate (IR) of childhood cancer was 176.3/1,000,000 children under 15 years of age. The lowest IR among both boys and girls was observed in district 22 (69.4/1,000,000) and the highest was observed in district 6 (242.09/1,000,000). The detection of clusters was performed for all cancer sites. All the cancer sites combined category showed clustering in the districts 7, 13, 8, 6, 3, 14, 12, 11, and 4. For this category, the clustering likelihood was marginally statistically significant (p-value=0.056), with an overall relative risk of 1.30. No statistically significant patterns of clustering were detected for other categories.
本研究的目的是绘制德黑兰大都市区各区域儿童癌症发病率图谱，并探究该地区不同环境中癌症病例可能存在的聚集情况。1998年至2002年期间，从三个来源确定了德黑兰市22个区域内所有15岁以下儿童癌症发病病例。确定了每个病例的居住地点地理坐标。使用扫描统计聚类检测技术评估德黑兰全市的病例聚集情况。儿童癌症总体发病率为每100万名15岁以下儿童中有176.3例。在第22区观察到男孩和女孩的发病率最低（69.4/1,000,000），在第6区观察到的发病率最高（242.09/1,000,000）。对所有癌症部位进行了聚类检测。所有癌症部位合并类别在第7、13、8、6、3、14、12、11和4区显示出聚集情况。对于该类别，聚类可能性在统计学上具有微弱显著性（p值=0.056），总体相对风险为1.30。其他类别未检测到具有统计学显著性的聚集模式。
