卵母细胞冷冻保存
Oocyte cryopreservation.
作者信息
Jain John K, Paulson Richard J
机构信息
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
出版信息
Fertil Steril. 2006 Oct;86(4 Suppl):1037-46. doi: 10.1016/j.fertnstert.2006.07.1478.
OBJECTIVE
To review historical and contemporary advances in oocyte-cryopreservation techniques and outcomes.
DESIGN
Publications related to oocyte cryopreservation were identified through MEDLINE and other bibliographic databases.
CONCLUSION(S): Oocyte cryopreservation can be used as an adjunct to conventional IVF and as an option for fertile women to electively cryopreserve their gametes. Recent reports indicate pregnancy rates comparable to those for cryopreserved embryos by either slow-freeze or vitrification methods. Larger prospective trials are needed to determine the true efficacy and safety of oocyte cryopreservation. Until a sufficient number of births is reached and adequate outcome data are collected, oocyte cryopreservation should continue to be considered experimental and to be performed under the oversight of an institutional review board.
目的
回顾卵母细胞冷冻保存技术及结果的历史和当代进展。
设计
通过医学文献数据库（MEDLINE）及其他书目数据库检索与卵母细胞冷冻保存相关的出版物。
结论
卵母细胞冷冻保存可作为传统体外受精（IVF）的辅助手段，也可作为有生育能力的女性选择性冷冻其配子的一种选择。近期报告显示，通过慢速冷冻或玻璃化方法，其妊娠率与冷冻胚胎的妊娠率相当。需要进行更大规模的前瞻性试验，以确定卵母细胞冷冻保存的真正疗效和安全性。在达到足够数量的分娩并收集到充分的结局数据之前，卵母细胞冷冻保存应继续被视为实验性操作，并在机构审查委员会的监督下进行。
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