Lee Kai-Fai, Yeung William S B
Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Hum Fertil (Camb). 2006 Sep;9(3):137-43. doi: 10.1080/14647270600636467.
Fertilization and development of mouse embryos occur in the oviduct. Accumulating data suggested that embryo-maternal communication exists in the preimplantation period, with the female reproductive tract providing the optimal microenvironment conducive to the development of embryos. Signals produced from the developing embryos not only affect their own transport in the oviduct, but the physiology and gene expression patterns of the oviduct. As a step towards understanding the action of embryos on oviductal physiology, both genomics and proteomics approaches are being used to unveil the underlying mechanism of embryo-maternal interaction at the preimplantation stage. Results from recent studies allow us to better understand the roles and the use of oviductal secretory proteins or factors that affect embryo development in vivo and in vitro. It has been shown that in vitro culture alters gene expression of the cultured embryos and may predispose the embryo to certain disease. Therefore, the interaction between gamete/embryo and oviduct in vitro and in vivo, and the long-term effects of embryo culture on foetal development warrant further investigation.
小鼠胚胎的受精和发育在输卵管中进行。越来越多的数据表明，在植入前阶段存在胚胎与母体的交流，雌性生殖道提供了有利于胚胎发育的最佳微环境。发育中的胚胎产生的信号不仅影响其在输卵管中的运输，还影响输卵管的生理和基因表达模式。作为理解胚胎对输卵管生理作用的一步，基因组学和蛋白质组学方法都被用于揭示植入前阶段胚胎与母体相互作用的潜在机制。最近的研究结果使我们能够更好地理解影响体内和体外胚胎发育的输卵管分泌蛋白或因子的作用及用途。研究表明，体外培养会改变培养胚胎的基因表达，并可能使胚胎易患某些疾病。因此，配子/胚胎与输卵管在体内外的相互作用，以及胚胎培养对胎儿发育的长期影响值得进一步研究。
