同源物种的甘丙肽抑制大鼠和猪的胰岛素分泌。

Galanin of the homologous species inhibits insulin secretion in the rat and in the pig.

作者信息

Lindskog S, Dunning B E, Mårtensson H, Ar'Rajab A, Taborsky G J, Ahrén B

机构信息

Department of Pharmacology, University of Lund, Sweden.

出版信息

Acta Physiol Scand. 1990 Aug;139(4):591-6. doi: 10.1111/j.1748-1716.1990.tb08963.x.

DOI:10.1111/j.1748-1716.1990.tb08963.x

PMID:1701068

Abstract

It is known that pig galanin inhibits insulin secretion in dogs, rats and mice. The present study examined whether species-specific, homologous, galanin inhibits insulin secretion. Thus, the effects of rat galanin were examined in the rat, and the effects of pig galanin were examined in the pig, both in vivo and in vitro. In conscious rats, synthetic rat galanin (2 nmol kg-1) abolished the glucose- (0.56 mmol kg-1) induced increase in plasma insulin levels. In vitro, rat galanin (10(-9) to 10(-6) mol l-1) inhibited glucose- (8.3 mmol l-1) stimulated insulin release from isolated rat islets. In anaesthetized pigs, 15 min infusion of synthetic pig galanin (207 pmol min-1) into the pancreatic artery decreased the insulin output with a subsequent recovery. In vitro, pig galanin (10(-6) mol l-1) inhibited glucose- (8.3 mmol l-1) stimulated insulin release from isolated pig islets. We conclude that homologous galanin inhibits insulin secretion in both the rat and the pig.

摘要

已知猪甘丙肽可抑制犬、大鼠和小鼠的胰岛素分泌。本研究检测了物种特异性的同源甘丙肽是否会抑制胰岛素分泌。因此，分别在大鼠体内和体外研究了大鼠甘丙肽的作用，以及在猪体内和体外研究了猪甘丙肽的作用。在清醒大鼠中，合成的大鼠甘丙肽（2 nmol·kg-1）消除了葡萄糖（0.56 mmol·kg-1）诱导的血浆胰岛素水平升高。在体外，大鼠甘丙肽（10-9至10-6 mol·l-1）抑制葡萄糖（8.3 mmol·l-1）刺激的离体大鼠胰岛胰岛素释放。在麻醉猪中，向胰动脉内输注合成猪甘丙肽（207 pmol·min-1）15分钟可降低胰岛素分泌量，随后恢复。在体外，猪甘丙肽（10-6 mol·l-1）抑制葡萄糖（8.3 mmol·l-1）刺激的离体猪胰岛胰岛素释放。我们得出结论，同源甘丙肽在大鼠和猪体内均会抑制胰岛素分泌。