拉沙病毒糖蛋白：针对GP1的合成肽的抗原性和免疫原性特性
Lassa virus glycoproteins: antigenic and immunogenic properties of synthetic peptides to GP1.
作者信息
Krasko A G, Moshnikova A B, Kozhich A T, Tchikin L D, Ivanov V T, Vladyko A S, Lukashevich I S
机构信息
Department of Special Pathogens, Byelorussian Research Institute of Epidemiology and Microbiology, Minsk, U.S.S.R.
出版信息
Arch Virol. 1990;115(1-2):133-7. doi: 10.1007/BF01310630.
Synthetic peptides corresponding to predicted Lassa virus GP1 glycoprotein B-epitopes were used to study the antigenicity and immunogenicity of the protein. ELISA results showed that guinea pig polyclonal anti-Lassa virus serum bound effectively to peptides corresponding to amino acid residues 119-133 and 164-176 of the GP1 protein. Essentially it did not react to a peptide corresponding to GP1 amino acid residues 234-256. Sera obtained against peptides representing amino acid residues 119-133 and 164-176 reacted with inactivated purified Lassa virus.
与预测的拉沙病毒糖蛋白GP1 B表位相对应的合成肽被用于研究该蛋白的抗原性和免疫原性。酶联免疫吸附测定（ELISA）结果显示，豚鼠抗拉沙病毒多克隆血清能有效结合与GP1蛋白氨基酸残基119 - 133和164 - 176相对应的肽段。基本上，它不与与GP1氨基酸残基234 - 256相对应的肽段发生反应。针对代表氨基酸残基119 - 133和164 - 176的肽段产生的血清能与灭活的纯化拉沙病毒发生反应。
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