Kleinmann Guy, Apple David J, Chew Jesse, Hunter Brian, Stevens Scott, Larson Scott, Mamalis Nick, Olson Randall J
David J Apple, MD, Laboratories for Ophthalmic Research, John A Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA.
J Cataract Refract Surg. 2006 Oct;32(10):1717-21. doi: 10.1016/j.jcrs.2006.04.033.
To evaluate the ability and safety of a hydrophilic acrylic intraocular lens (IOL) as a drug-delivery system for commercially available gatifloxacin and moxifloxacin.
David J. Apple, MD, Laboratories for Ophthalmic Research, John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah, USA.
Thirty rabbits were divided into 2 similar groups. In Group A (15 rabbits, 30 eyes), hydrophilic acrylic IOLs (C-flex, Rayner Intraocular Lenses, Ltd.) presoaked for 24 hours in commercially available solutions of gatifloxacin 3 mg/mL or moxifloxacin 5 mg/mL were implanted after evacuation of the crystalline lens. Group B (15 rabbits, 30 eyes) had topical preoperative and postoperative cataract prophylaxis with gatifloxacin 3 mg/mL or moxifloxacin 5 mg/mL; IOLs that were not presoaked were also implanted after evacuation of the crystalline lenses. In both groups, aqueous humor samples were taken 4, 8, or 12 hours after IOL implantation (5 eyes at each time point) to determine the antibiotic concentrations. Clinical examinations were performed 24 hours postoperatively.
The antibiotic concentrations in Group A (presoaked IOLs) were statistically significantly higher than those in Group B (topical) for both antibiotics in all postoperative samples except moxifloxacin at 12 hours. In both groups, there was no statistically significant difference between the concentrations of the 2 antibiotics. No eye showed signs of clinical toxicity.
Results show the C-flex IOL is a safe and effective drug-delivery system for fourth-generation fluoroquinolones.
评估亲水性丙烯酸人工晶状体（IOL）作为市售加替沙星和莫西沙星药物递送系统的能力及安全性。
美国犹他州盐湖城犹他大学眼科与视觉科学系约翰·A·莫兰眼科中心大卫·J·阿普尔医学博士眼科研究实验室。
30只兔子被分为2个相似的组。A组（15只兔子，30只眼），在摘除晶状体后植入预先在3 mg/mL加替沙星或5 mg/mL莫西沙星市售溶液中浸泡24小时的亲水性丙烯酸IOL（C-flex，Rayner人工晶状体有限公司）。B组（15只兔子，30只眼）术前和术后用3 mg/mL加替沙星或5 mg/mL莫西沙星进行局部白内障预防；在摘除晶状体后也植入未预先浸泡的IOL。两组在IOL植入后4、8或12小时（每个时间点5只眼）采集房水样本以测定抗生素浓度。术后24小时进行临床检查。
除12小时的莫西沙星外，A组（预先浸泡的IOL）所有术后样本中两种抗生素的浓度在统计学上均显著高于B组（局部用药组）。两组中，两种抗生素的浓度之间无统计学显著差异。没有眼睛显示出临床毒性迹象。
结果表明C-flex IOL是一种用于第四代氟喹诺酮类药物的安全有效的药物递送系统。
