Schulz-Ertner Daniela, Jäkel Oliver, Schlegel Wolfgang
Department of Radiation Oncology, University of Heidelberg, Germany.
Semin Radiat Oncol. 2006 Oct;16(4):249-59. doi: 10.1016/j.semradonc.2006.04.008.
Charged particle beams can offer an improved dose conformation to the target volume as compared with photon radiotherapy, with better sparing of normal tissue structures close to the target. In addition, beams of ions heavier than (4)He exhibit a strong increase of the linear energy transfer in the Bragg peak as compared with the entrance region. These physical and biological properties are much more favorable than in photon radiotherapy. As a consequence, particle therapy with protons and heavy ions has gained increasing interest worldwide, and many clinical centers are considering introducing radiation therapy with charged particles. This contribution summarizes the physical and technical principles of charged particle therapy with protons and heavy ions. It briefly reviews the clinical experience gathered so far with proton therapy and gives a more detailed summary of the recent results in carbon ion therapy of skull base tumors, head and neck tumors, non-small-cell lung cancer, hepatocellular carcinomas, bone and soft-tissue sarcomas, and prostate cancer.
与光子放射治疗相比，带电粒子束可为靶区提供更好的剂量适形，对靠近靶区的正常组织结构有更好的保护。此外，比氦（4）重的离子束在布拉格峰处的线能量传递比入射区域有显著增加。这些物理和生物学特性比光子放射治疗更有利。因此，质子和重离子粒子治疗在全球范围内越来越受到关注，许多临床中心正在考虑引入带电粒子放射治疗。本文总结了质子和重离子带电粒子治疗的物理和技术原理。简要回顾了迄今为止质子治疗积累的临床经验，并更详细地总结了碳离子治疗颅底肿瘤、头颈部肿瘤、非小细胞肺癌、肝细胞癌、骨与软组织肉瘤以及前列腺癌的近期结果。
