小鼠染色体着丝粒异染色质的间断性凝聚不足：在经Hoechst 33258处理的细胞中的证据
Discontinuous undercondensation of centromeric heterochromatin in mouse chromosomes: evidence in Hoechst 33258-treated cells.
作者信息
de la Torre J, Goyanes V, Gosálvez J
机构信息
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
出版信息
Cytogenet Cell Genet. 1990;54(1-2):55-7. doi: 10.1159/000132954.
Mouse chromosomes from the L929 cell line have been treated with Hoechst 33258 to induce undercondensation of centromeric heterochromatin. The morphological changes induced by this fluorochrome were analyzed in electron micrographs of whole-mounted chromosomes. Results show that the condensation inhibition of centromeric heterochromatin caused by Hoechst 33258 is not produced homogeneously and suggest compositional differences within an individual centromere.
来自L929细胞系的小鼠染色体已用Hoechst 33258处理，以诱导着丝粒异染色质的凝聚不足。在整装染色体的电子显微照片中分析了这种荧光染料诱导的形态变化。结果表明，Hoechst 33258引起的着丝粒异染色质凝聚抑制并非均匀产生，这表明单个着丝粒内存在组成差异。
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