Payne Jennifer L, Roy Patricia S, Murphy-Eberenz Kathleen, Weismann Myrna M, Swartz Karen L, McInnis Melvin G, Nwulia Eva, Mondimore Francis M, MacKinnon Dean F, Miller Erin B, Nurnberger John I, Levinson Douglas F, DePaulo J Raymond, Potash James B
Department of Psychiatry, Women's Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street/Meyer 3-181, Baltimore, MD 21287-7381, United States.
J Affect Disord. 2007 Apr;99(1-3):221-9. doi: 10.1016/j.jad.2006.08.013. Epub 2006 Oct 2.
We sought to determine the prevalence of, and association between, reproductive cycle-associated mood symptoms in women with affective disorders. We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP).
2412 women with, MDD or BP were asked standardized questions about mood symptoms prior to menstruation, within a month of childbirth and during perimenopause. Lifetime rates for each of these symptom types were determined and an odds ratio was calculated correlating each of the types with the others.
Of 2524 women with mood disorders, 67.7% reported premenstrual symptoms. Of those at risk, 20.9% reported postpartum symptoms and 26.4% reported perimenopausal symptoms. The rates did not differ between women with MDD and BP but were significantly different from women who were never ill. The symptoms were significantly correlated in women with MDD with odds ratios from 1.66 to 1.82, but were not in women with BP.
This is a secondary analysis of a sample that was collected for other purposes and is based upon retrospective reporting.
Reproductive cycle-associated mood symptoms were commonly reported in women with mood disorders and did not differ based on diagnosis. In MDD, but not BP, the occurrence of these symptoms was trait-like as the presence of one predicted the occurrence of the others. Further prospective study is required to clarify the determinants of this trait.
我们试图确定情感障碍女性中与生殖周期相关的情绪症状的患病率及其之间的关联。我们假设，在重度抑郁症（MDD）和双相I型障碍（BP）中，这些症状在女性的整个生殖寿命中会相互关联。
对2412名患有MDD或BP的女性询问了关于月经前、分娩后一个月内以及围绝经期情绪症状的标准化问题。确定了每种症状类型的终生患病率，并计算了每种类型与其他类型相关的比值比。
在2524名患有情绪障碍的女性中，67.7%报告有经前症状。在有风险的女性中，20.9%报告有产后症状，26.4%报告有围绝经期症状。MDD和BP女性的患病率没有差异，但与从未患病的女性有显著差异。MDD女性的症状显著相关，比值比为1.66至1.82，但BP女性则不然。
这是对为其他目的收集的样本进行的二次分析，且基于回顾性报告。
情绪障碍女性中普遍报告有与生殖周期相关的情绪症状，且不因诊断而异。在MDD中，而非BP中，这些症状的出现具有特质性，因为一种症状的出现预示着其他症状的出现。需要进一步的前瞻性研究来阐明这种特质的决定因素。
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