Zhang Jianping, Niaura Raymond, Dyer Joshua R, Shen Biing-Jiun, Todaro John F, McCaffery Jeanne M, Spiro Avron, Ward Kenneth D
Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, USA.
Psychosom Med. 2006 Sep-Oct;68(5):718-26. doi: 10.1097/01.psy.0000228343.89466.11.
Previous research has produced mixed results pertaining to the association between hostility and insulin resistance. These inconsistent findings may be the result of a lack of studies examining potential moderators of this relationship and inconsistent measures of insulin resistance and/or hostility. We hypothesized that hostility may interact with circulating norepinephrine (NEPI) levels, indexed by 24-hour urine concentrations, to affect insulin resistance.
Six hundred forty-three men (mean age = 63.1 years) free of diabetic medications completed the Minnesota Multiphasic Personality Inventory and participated in a laboratory assessment. The Cook-Medley Hostility (Ho) and 24-hour urine NEPI were used to predict insulin resistance defined by the homeostatic model assessment (HOMA) index, 2-hour postchallenge glucose (PCGL), and insulin levels (PCIL) after controlling for nine common covariates.
Multiple regression showed that the two-way interaction between Ho and NEPI significantly predicted HOMA and PCIL, but not PCGL, after controlling for covariates. Simple regression slopes of Ho on HOMA and PCIL were explored and indicated that, at higher levels of NEPI, higher Ho was associated with higher HOMA (beta = 0.14, p < .05). Ho was not a significant predictor of HOMA at mean and lower levels of NEPI. Similar results were obtained for PCIL, but not PCGL. Cynicism, but not other subscales of Ho, was similarly related to insulin resistance and NEPI.
Individuals with high stress and high hostility were more likely to have insulin resistance. It is important to study moderators in the relationship between hostility and insulin resistance.
先前的研究在敌意与胰岛素抵抗之间的关联方面得出了混合结果。这些不一致的发现可能是由于缺乏对这种关系潜在调节因素的研究，以及胰岛素抵抗和/或敌意的测量方法不一致所致。我们假设敌意可能与以24小时尿浓度为指标的循环去甲肾上腺素（NEPI）水平相互作用，从而影响胰岛素抵抗。
643名未服用糖尿病药物的男性（平均年龄 = 63.1岁）完成了明尼苏达多相人格问卷并参与了实验室评估。在控制了九个常见协变量后，使用库克-梅德利敌意量表（Ho）和24小时尿NEPI来预测由稳态模型评估（HOMA）指数、挑战后2小时血糖（PCGL）和胰岛素水平（PCIL）定义的胰岛素抵抗。
多元回归显示，在控制协变量后，Ho和NEPI之间的双向交互作用显著预测了HOMA和PCIL，但未预测PCGL。探索了Ho对HOMA和PCIL的简单回归斜率，结果表明，在较高的NEPI水平下，较高的Ho与较高的HOMA相关（β = 0.14，p <.05）。在NEPI的平均水平和较低水平下，Ho不是HOMA的显著预测因素。PCIL也得到了类似的结果，但PCGL没有。愤世嫉俗，而不是Ho的其他子量表，与胰岛素抵抗和NEPI有类似的关系。
高压力和高敌意的个体更有可能出现胰岛素抵抗。研究敌意与胰岛素抵抗之间关系的调节因素很重要。
