Yoshida Toru, Kondo Norihiko, Oka Shin-ichi, Ahsan Md Kaimul, Hara Tomijiro, Masutani Hiroshi, Nakamura Hajime, Yodoi Junji
Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara-cho Sakyo-ku, Kyoto 606-8507, Japan.
Biofactors. 2006;27(1-4):47-51. doi: 10.1002/biof.5520270105.
Thioredoxin (TRX) binding protein-2 (TBP-2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP-2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP-2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP-2 was also reported to be a cellular senescence-associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP-2 genetically modified mice and found that TBP-2 is closely linked to lipid metabolism. Indeed, TBP-2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP-2 in the regulation of energy utilization connected to the aging process.
硫氧还蛋白（TRX）结合蛋白-2（TBP-2）是TRX的负调节因子，参与细胞内氧化还原调节和细胞生长。TBP-2的表达在肿瘤细胞系和组织中经常缺失，而TBP-2的异位表达会抑制细胞增殖，并使细胞周期停滞在G1期。据报道，TBP-2也是一种细胞衰老相关基因。除了细胞生长迟缓外，白色脂肪减少和能量途径改变也参与衰老过程的几个特征。我们构建了TBP-2基因修饰小鼠，并发现TBP-2与脂质代谢密切相关。事实上，通过一个自发突变小鼠品系分析表明，TBP-2与家族性混合性高脂血症有关。由于脂质代谢是能量产生的最原始来源之一，我们讨论了TBP-2在与衰老过程相关的能量利用调节中的可能作用。
