Vosshenrich Christian A J, García-Ojeda Marcos E, Samson-Villéger Sandrine I, Pasqualetto Valerie, Enault Laurence, Richard-Le Goff Odile, Corcuff Erwan, Guy-Grand Delphine, Rocha Benedita, Cumano Ana, Rogge Lars, Ezine Sophie, Di Santo James P
Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F-75724, France.
Nat Immunol. 2006 Nov;7(11):1217-24. doi: 10.1038/ni1395. Epub 2006 Oct 1.
Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus. Thymus-derived CD127+ NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. Those characteristics are reminiscent of human CD56(hi) CD16- NK cells, which we found expressed CD127 and had more GATA-3 expression than human CD56+ CD16+ NK cells. We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets.
自然杀伤（NK）细胞的发育被认为发生在骨髓中。在此，我们确定转录因子GATA-3和CD127（白细胞介素-7受体α）是源自胸腺的小鼠NK细胞发育途径的分子标志物。胸腺来源的CD127⁺ NK细胞重新填充外周淋巴器官，其稳态严格依赖于GATA-3和白细胞介素7。CD127⁺ NK细胞具有独特的表型（CD11b(lo) CD16⁻ CD69(hi) Ly49(lo)）和不同寻常的功能特性，包括细胞毒性降低但细胞因子产生相当可观。这些特征使人联想到人类CD56(hi) CD16⁻ NK细胞，我们发现其表达CD127，且比人类CD56⁺ CD16⁺ NK细胞有更多的GATA-3表达。我们提出，骨髓和胸腺NK细胞途径产生具有与两个人类CD56 NK细胞亚群相似特性的不同小鼠NK细胞。
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