Stevens James, Blixt Ola, Paulson James C, Wilson Ian A
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Nat Rev Microbiol. 2006 Nov;4(11):857-64. doi: 10.1038/nrmicro1530. Epub 2006 Oct 2.
New technologies are urgently required for rapid surveillance of the current H5N1 avian influenza A outbreaks to gauge the potential for adaptation of the virus to the human population, a crucial step in the emergence of pandemic influenza virus strains. Owing to the species-specific nature of the interaction between the virus and host glycans, attention has recently focused on novel glycan array technologies that can rapidly assess virus receptor specificity and the potential emergence of human-adapted H5N1 viruses.
迫切需要新技术来快速监测当前甲型H5N1禽流感疫情，以评估病毒适应人类的可能性，这是大流行性流感病毒株出现的关键一步。由于病毒与宿主聚糖之间相互作用具有物种特异性，最近人们将注意力集中在新型聚糖阵列技术上，该技术可以快速评估病毒受体特异性以及人源化H5N1病毒的潜在出现情况。
