Conway G S, Jacobs H S, Holly J M, Wass J A
Department of Endocrinology, Middlesex Hospital, London, UK.
Clin Endocrinol (Oxf). 1990 Nov;33(5):593-603. doi: 10.1111/j.1365-2265.1990.tb03897.x.
This study explores the clinical and endocrine implications of hyperinsulinaemia in the polycystic ovary syndrome (PCOS). Oral glucose tolerance tests were performed on 34 lean and 19 obese women with PCOS and on 13 lean women with normal ovaries. Insulin measurements were compared with basal gonadotrophins, androgens, insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein 1 (IGFBP-1). Unselected lean women with PCOS were found to have fasting hyperinsulinaemia and the raised serum insulin concentrations were associated with menstrual disturbance and hyperandrogenaemia. In addition, serum insulin concentrations in lean women with PCOS correlated positively with serum IGF-I and negatively with serum IGFBP-1 concentrations. Ovarian stimulation by insulin appears to be independent of luteinizing hormone (LH) and is an important feature in 30% of lean women with PCOS.
本研究探讨多囊卵巢综合征（PCOS）中高胰岛素血症的临床及内分泌学意义。对34名体重正常的PCOS女性、19名肥胖的PCOS女性以及13名卵巢功能正常的体重正常女性进行了口服葡萄糖耐量试验。将胰岛素测量结果与基础促性腺激素、雄激素、胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白1（IGFBP-1）进行比较。发现未经选择的体重正常的PCOS女性存在空腹高胰岛素血症，血清胰岛素浓度升高与月经紊乱和高雄激素血症相关。此外，体重正常的PCOS女性血清胰岛素浓度与血清IGF-I呈正相关，与血清IGFBP-1浓度呈负相关。胰岛素对卵巢的刺激作用似乎独立于黄体生成素（LH），在30%的体重正常的PCOS女性中是一个重要特征。
