Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Sci Rep. 2021 May 13;11(1):10226. doi: 10.1038/s41598-021-89232-1.
The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively associated with lean mass and strength in young and older males. Whether this relationship exists in pre-menopausal females is unknown. Secondary data from the 2013-2014 National Health and Nutrition Examination Survey were used to test this relationship. Females were aged 18-40 (n = 716, age 30 ± 6 years, mean ± SD) and pre-menopausal. Multivariate linear regression models were used to examine associations between total testosterone, lean mass index (LMI) and handgrip strength. Mean ± SD testosterone concentration was 1.0 ± 0.6 nmol L and mean free androgen index (FAI) was 0.02 ± 0.02. In pre-menopausal females, testosterone was not associated with LMI (β = 0.05; 95%CI - 0.04, 0.15; p = 0.237) or handgrip strength (β = 0.01; 95%CI - 0.11, 0.12; p = 0.926) in a statistically significant manner. Conversely, FAI was associated with LMI (β = - 0.03; 95%CI - 0.05, - 0.02; p = 0.000) in a quadratic manner, meaning LMI increases with increasing FAI levels. Handgrip strength was not associated with FAI (β = 0.06; 95%CI - 0.02, 0.15; p = 0.137). These findings indicate that FAI, but not total testosterone, is associated with LMI in pre-menopausal females. Neither FAI nor total testosterone are associated with handgrip strength in pre-menopausal females when testosterone concentrations are not altered pharmacologically.
这项研究的目的是检验内源性睾丸酮浓度与健康、绝经前女性的瘦体重和握力之间的关系。睾丸酮与年轻和老年男性的瘦体重和力量呈正相关。这种关系是否存在于绝经前女性中尚不清楚。使用 2013-2014 年全国健康与营养调查的二级数据来检验这种关系。女性年龄在 18-40 岁（n=716，年龄 30±6 岁，均值±标准差），处于绝经前阶段。采用多元线性回归模型来检验总睾丸酮、瘦体重指数（LMI）和握力之间的关系。平均±标准差睾丸酮浓度为 1.0±0.6 nmol/L，平均游离雄激素指数（FAI）为 0.02±0.02。在绝经前女性中，睾丸酮与 LMI（β=0.05；95%CI - 0.04，0.15；p=0.237）或握力（β=0.01；95%CI - 0.11，0.12；p=0.926）之间无统计学显著关联。相反，FAI 与 LMI 呈二次关联（β=-0.03；95%CI - 0.05，- 0.02；p=0.000），这意味着 LMI 随着 FAI 水平的升高而增加。握力与 FAI 无关联（β=0.06；95%CI - 0.02，0.15；p=0.137）。这些发现表明，在绝经前女性中，FAI 而非总睾丸酮与 LMI 相关。当睾丸酮浓度未发生药物改变时，FAI 或总睾丸酮均与绝经前女性的握力无关。
