蛙皮素对犬血浆胰蛋白酶释放及胰腺外分泌的刺激作用。

Stimulatory effects of bombesin on plasma trypsin release and exocrine pancreatic secretion in dogs.

作者信息

Kiriyama S, Hayakawa T, Kondo T, Shibata T, Kitagawa M, Sakai Y, Sobajima H, Ikei N, Kodaira T, Hamaoka T

机构信息

2nd Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Digestion. 1990;46(2):81-8. doi: 10.1159/000200336.

DOI:10.1159/000200336

PMID:1701403

Abstract

We examined the effect of bombesin on plasma trypsin release and exocrine pancreatic secretion in dogs. Bombesin significantly increased plasma immunoreactive trypsin (IRT). Atropine significantly inhibited the response of plasma IRT to bombesin. Pancreatic trypsin secretion was also increased by bombesin, as well as bicarbonate and protein outputs. Atropine failed to inhibit pancreatic trypsin secretion. In conclusion, bombesin has a stimulatory effect on plasma trypsin release mediated by a cholinergic mechanism and different from pancreatic secretion.

摘要

我们研究了蛙皮素对犬血浆胰蛋白酶释放及胰腺外分泌的影响。蛙皮素显著增加血浆免疫反应性胰蛋白酶（IRT）。阿托品显著抑制血浆IRT对蛙皮素的反应。蛙皮素还可增加胰腺胰蛋白酶分泌，以及碳酸氢盐和蛋白质的分泌量。阿托品未能抑制胰腺胰蛋白酶分泌。总之，蛙皮素对由胆碱能机制介导且不同于胰腺分泌的血浆胰蛋白酶释放具有刺激作用。