阿托品和生长抑素对蛙皮素刺激的人血浆免疫反应性胰蛋白酶释放的影响。

Effect of atropine and somatostatin on bombesin-stimulated plasma immunoreactive trypsin release in man.

作者信息

de Jong A J, Klamer M, Lamers C B

机构信息

Department of Gastroenterology and Hepatology, St. Radboud Hospital, Nijmegen, The Netherlands.

出版信息

Digestion. 1987;37(3):156-9. doi: 10.1159/000199493.

DOI:10.1159/000199493

PMID:2888697

Abstract

This study was undertaken to determine the effect of atropine and somatostatin, two inhibitors of intraduodenal pancreatic enzyme secretion, on bombesin-stimulated release of plasma immunoreactive trypsin in 6 healthy volunteers. Infusion of 5 ng/kg.min bombesin during 30 min induced significant increases in plasma trypsin from 206 +/- 20 to 334 +/- 44 ng/ml (p less than 0.01). Atropine (15 ng/kg as i.v. bolus followed by 5 ng/kg.h) had no influence on the bombesin-stimulated increase in plasma immunoreactive trypsin (207 +/- 20 to 326 +/- 54 ng/ml). Somatostatin (125 micrograms as i.v. bolus followed by 125 micrograms/h) also failed to inhibit the plasma trypsin response to bombesin (207 +/- 18 to 663 +/- 166 ng/ml). These results point to major differences in the regulation of plasma and intraduodenal trypsin secretion.

摘要

本研究旨在确定两种十二指肠内胰酶分泌抑制剂——阿托品和生长抑素，对6名健康志愿者中蛙皮素刺激的血浆免疫反应性胰蛋白酶释放的影响。在30分钟内输注5 ng/kg·min的蛙皮素可使血浆胰蛋白酶从206±20显著增加至334±44 ng/ml（p<0.01）。阿托品（静脉推注15 ng/kg，随后以5 ng/kg·h输注）对蛙皮素刺激引起的血浆免疫反应性胰蛋白酶增加无影响（从207±20至326±54 ng/ml）。生长抑素（静脉推注125μg，随后以125μg/h输注）也未能抑制血浆胰蛋白酶对蛙皮素的反应（从207±18至663±166 ng/ml）。这些结果表明血浆和十二指肠内胰蛋白酶分泌的调节存在重大差异。