Maestripieri Dario, Higley J Dee, Lindell Stephen G, Newman Timothy K, McCormack Kai M, Sanchez Mar M
Department of Comparative Human Development, The University of Chicago, Chicago, IL 60637, USA.
Behav Neurosci. 2006 Oct;120(5):1017-24. doi: 10.1037/0735-7044.120.5.1017.
This study investigated the effects of early exposure to variable parenting style and infant abuse on cerebrospinal fluid (CSF) concentrations of monoamine metabolites and examined the role of monoaminergic function in the intergenerational transmission of infant abuse in rhesus monkeys (Macaca mulatta). Forty-three infants reared by their biological mothers and 15 infants that were cross-fostered at birth and reared by unrelated mothers were followed longitudinally through their first 3 years of life or longer. Approximately half of the infants were reared by abusive mothers and half by nonabusive controls. Abused infants did not differ from controls in CSF concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), or 3-methoxy-4-hydroxyphenylgycol (MHPG). Abused infants, however, were exposed to higher rates of maternal rejection, and highly rejected infants had lower CSF 5-HIAA and HVA than low-rejection infants. The abused females who became abusive mothers in adulthood had lower CSF 5-HIAA than the abused females who did not. A similar trend was also observed among the cross-fostered females, suggesting that low serotonergic function resulting from early exposure to high rates of maternal rejection plays a role in the intergenerational transmission of infant abuse.
本研究调查了早期接触可变育儿方式和婴儿虐待对脑脊液（CSF）中单胺代谢物浓度的影响，并探讨了单胺能功能在恒河猴（猕猴）婴儿虐待代际传递中的作用。43只由亲生母亲抚养的幼猴和15只出生时被交叉寄养并由无血缘关系的母亲抚养的幼猴，在其生命的前3年或更长时间内进行了纵向跟踪。大约一半的幼猴由虐待性母亲抚养，另一半由非虐待性对照母亲抚养。受虐待幼猴的脑脊液中5-羟吲哚乙酸（5-HIAA）、高香草酸（HVA）或3-甲氧基-4-羟基苯乙二醇（MHPG）的浓度与对照幼猴没有差异。然而，受虐待幼猴遭受母亲拒绝的比例更高，且被高度拒绝的幼猴脑脊液中5-HIAA和HVA的含量低于低拒绝率的幼猴。成年后成为虐待性母亲的受虐待雌性幼猴脑脊液中5-HIAA的含量低于未成为虐待性母亲的受虐待雌性幼猴。在交叉寄养的雌性幼猴中也观察到了类似的趋势，这表明早期接触高比例的母亲拒绝所导致的低血清素能功能在婴儿虐待的代际传递中起作用。
