Janik Joseph P, Bang Ran H
Department of Dermatology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87102, USA.
Pediatr Dermatol. 2006 Sep-Oct;23(5):448-50. doi: 10.1111/j.1525-1470.2006.00280.x.
Keratoacanthomas appear most commonly in sun-damaged skin in middle-aged and elderly people. We present a 15-year-old boy who developed a rapidly growing nodule within a hypertrophic scar that was the result of trauma suffered in a roll-over motor vehicle accident 8 months prior to presentation. Histologic analysis of a biopsy specimen of the nodule confirmed the presence of squamous cell carcinoma, keratoacanthoma type. The development of keratoacanthoma has been associated with sun exposure, chemical carcinogens, radiation therapy, genetic factors, and various forms of antecedent trauma, including surgery or grafting, thermal burns, laser resurfacing, and vaccination. This report describes the youngest patient with traumatically-induced keratoacanthoma, and is the first instance of this entity arising in a friction burn.
角化棘皮瘤最常见于中老年受阳光损伤的皮肤。我们报告一名15岁男孩,在肥厚性瘢痕内出现一个迅速生长的结节,该瘢痕是8个月前翻车机动车事故所致创伤的结果。对该结节活检标本的组织学分析证实存在鳞状细胞癌,角化棘皮瘤型。角化棘皮瘤的发生与阳光照射、化学致癌物、放射治疗、遗传因素以及各种形式的先前创伤有关,包括手术或移植、热烧伤、激光换肤和接种疫苗。本报告描述了最年轻的创伤性角化棘皮瘤患者,也是该实体在摩擦烧伤中出现的首例。