Ma D, Gu M J, Liu B Q
Department of Gynecology and Obstetrics, Tongji Hospital, Tongji University, Wuhan.
J Tongji Med Univ. 1990;10(3):159-63. doi: 10.1007/BF02986455.
A release assay of 125IUdR-labelled K562 cells as target cells was performed for measuring natural killer (NK) activity of mononuclear cells in the peripheral blood of 92 cases, including 42 healthy women, 22 patients with gynecological benign tumors, and 28 patients with gynecological malignancies. The NK activity of malignant tumor group was obviously lower than that of healthy women and of benign tumor group, suggesting that a defective NK activity was present in the patients with gynecological malignancies. The NK activity in patients with ovarian malignant tumors was much lower than in those with cervical cancer, the difference being of statistical significance. In this study the leukocyte interferon was investigated for its effects on the NK activity of peripheral blood mononuclear cells from 4 cases of gynecological malignancies. The level of NK activity ascended significantly in every case nearly to normal. The augmentation of NK activity by interferon may be used as a new immunotherapy for gynecological malignancies.
采用以125IUdR标记的K562细胞为靶细胞的释放试验，检测了92例患者外周血单个核细胞的自然杀伤（NK）活性，其中包括42例健康女性、22例妇科良性肿瘤患者和28例妇科恶性肿瘤患者。恶性肿瘤组的NK活性明显低于健康女性组和良性肿瘤组，提示妇科恶性肿瘤患者存在NK活性缺陷。卵巢恶性肿瘤患者的NK活性远低于宫颈癌患者，差异具有统计学意义。本研究观察了白细胞干扰素对4例妇科恶性肿瘤患者外周血单个核细胞NK活性的影响。结果显示，每例患者的NK活性均显著升高，接近正常水平。干扰素增强NK活性可作为妇科恶性肿瘤的一种新的免疫治疗方法。
