Serrano M T, Vendrell M, Rivera S, Serratosa J, Rodríguez-Farré E
Department of Pharmacology and Toxicology, CSIC, Barcelona, Spain.
Neurotoxicol Teratol. 1990 Nov-Dec;12(6):577-83. doi: 10.1016/0892-0362(90)90065-k.
After lindane administration at several doses, brain myelin fractions of litters of male and female Wistar rats show a significant diminution of CNP (2',3'-cyclic nucleotide 3'-phosphodiesterase) activity. Furthermore, the immunohistochemical study of brains by means of a MBP (myelin basic protein) specific antibody reveals myelin deficits in some brain regions after lindane treatment. This loss of myelin protein is dose dependent. The deficit in myelin cannot be attributed to undernourishment of lindane-administered rats. This work shows the vulnerability of the developing central nervous system (CNS) to lindane and the correlation between a decrease in the CNPase activity and a deficit of MBP during the period of study of these animals.
以几种剂量给予林丹后，雄性和雌性Wistar大鼠幼崽的脑髓鞘组分显示2',3'-环核苷酸3'-磷酸二酯酶（CNP）活性显著降低。此外，通过髓鞘碱性蛋白（MBP）特异性抗体对脑进行免疫组织化学研究发现，林丹处理后一些脑区存在髓鞘缺陷。这种髓鞘蛋白的损失是剂量依赖性的。髓鞘缺陷不能归因于给予林丹的大鼠营养不良。这项研究表明发育中的中枢神经系统（CNS）对林丹具有易损性，并且在这些动物的研究期间，CNP酶活性降低与MBP缺乏之间存在相关性。
