Reinikainen K J, Pitkänen A, Riekkinen P J
Department of Neurology, University of Kuopio, Finland.
Neurosci Lett. 1989 Nov 20;106(1-2):229-32. doi: 10.1016/0304-3940(89)90230-9.
The activity of 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) was determined as an index of myelin in the post-mortem brain samples of 16 patients with Alzheimer's disease (AD) and of 14 controls. The CNPase activity was mildly increased in the temporal, hippocampal and parietal cortex in AD subjects pointing to a relative sparing of myelin as compared to the neuron loss within cortex in AD. In the hippocampus the CNPase activity was decreased in AD patients indicating loss of myelin and thus myelinated axons in this area in AD.
测定了16例阿尔茨海默病（AD）患者和14例对照者死后脑样本中2',3'-环核苷酸-3'-磷酸二酯酶（CNPase）的活性，以此作为髓鞘的指标。AD患者颞叶、海马和顶叶皮质中的CNPase活性轻度升高，这表明与AD患者皮质内神经元丢失相比，髓鞘相对保留。在海马中，AD患者的CNPase活性降低，表明该区域在AD中存在髓鞘丢失，进而存在有髓轴突丢失。
