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本文引用的文献

1
Pseudomonas aeruginosa lectin LecB is located in the outer membrane and is involved in biofilm formation.铜绿假单胞菌凝集素LecB位于外膜中，并参与生物膜的形成。
Microbiology (Reading). 2005 May;151(Pt 5):1313-1323. doi: 10.1099/mic.0.27701-0.
2
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.一种控制铜绿假单胞菌抽搐运动性的复杂化学感应信号转导系统的特性分析。
Mol Microbiol. 2004 May;52(3):873-93. doi: 10.1111/j.1365-2958.2004.04026.x.
3
PRODUCTION OF ELASTASE AND PROTEINASE BY PSEUDOMONAS AERUGINOSA.铜绿假单胞菌产生弹性蛋白酶和蛋白酶。
J Bacteriol. 1964 Sep;88(3):745-57. doi: 10.1128/jb.88.3.745-757.1964.
4
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants.铜绿假单胞菌野生型、鞭毛和IV型菌毛突变体的生物膜形成
Mol Microbiol. 2003 Jun;48(6):1511-24. doi: 10.1046/j.1365-2958.2003.03525.x.
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Application of zwitterionic detergents to the solubilization of integral membrane proteins for two-dimensional gel electrophoresis and mass spectrometry.两性离子去污剂在用于二维凝胶电泳和质谱分析的整合膜蛋白增溶中的应用。
Proteomics. 2002 Nov;2(11):1479-88. doi: 10.1002/1615-9861(200211)2:11<1479::AID-PROT1479>3.0.CO;2-A.
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Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.囊性纤维化患者肺部铜绿假单胞菌寡糖介导黏附的结构基础
Nat Struct Biol. 2002 Dec;9(12):918-21. doi: 10.1038/nsb865.
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The sugar code: functional lectinomics.糖密码：功能凝集素组学
Biochim Biophys Acta. 2002 Sep 19;1572(2-3):165-77. doi: 10.1016/s0304-4165(02)00306-9.
8
A novel type II secretion system in Pseudomonas aeruginosa.铜绿假单胞菌中的一种新型II型分泌系统。
Mol Microbiol. 2002 Jan;43(2):475-85. doi: 10.1046/j.1365-2958.2002.02759.x.
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Biological activities of carbohydrate-branched chitosan derivatives.
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Characterization of an endoprotease (PrpL) encoded by a PvdS-regulated gene in Pseudomonas aeruginosa.铜绿假单胞菌中由PvdS调控基因编码的一种内切蛋白酶（PrpL）的特性分析
Infect Immun. 2001 Sep;69(9):5385-94. doi: 10.1128/IAI.69.9.5385-5394.2001.

铜绿假单胞菌LecB参与菌毛生物合成和蛋白酶IV活性，但不参与对呼吸道粘蛋白的粘附。

Pseudomonas aeruginosa LecB is involved in pilus biogenesis and protease IV activity but not in adhesion to respiratory mucins.

作者信息

Sonawane Avinash, Jyot Jeevan, Ramphal Reuben

机构信息

Department of Medicine, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

出版信息

Infect Immun. 2006 Dec;74(12):7035-9. doi: 10.1128/IAI.00551-06. Epub 2006 Oct 2.

DOI:10.1128/IAI.00551-06
PMID:17015462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698087/
Abstract

Pseudomonas aeruginosa expresses two lectins which are implicated in adhesion and biofilm formation. In this study, we demonstrate that P. aeruginosa LecB is involved in pilus biogenesis and proteolytic activity. Moreover, neither lectin was involved in adhesion to human tracheobronchial mucin. We infer that some of the ascribed functions are secondary effects on other systems rather than effects of the lectins themselves.

摘要

铜绿假单胞菌表达两种凝集素，它们与黏附和生物膜形成有关。在本研究中，我们证明铜绿假单胞菌LecB参与菌毛生物合成和蛋白水解活性。此外，两种凝集素均不参与对人气管支气管黏蛋白的黏附。我们推断，一些所归因的功能是对其他系统的次要影响，而非凝集素本身的作用。