铜绿假单胞菌LecB参与菌毛生物合成和蛋白酶IV活性，但不参与对呼吸道粘蛋白的粘附。
Pseudomonas aeruginosa LecB is involved in pilus biogenesis and protease IV activity but not in adhesion to respiratory mucins.
作者信息
Sonawane Avinash, Jyot Jeevan, Ramphal Reuben
机构信息
Department of Medicine, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
出版信息
Infect Immun. 2006 Dec;74(12):7035-9. doi: 10.1128/IAI.00551-06. Epub 2006 Oct 2.
Abstract
Pseudomonas aeruginosa expresses two lectins which are implicated in adhesion and biofilm formation. In this study, we demonstrate that P. aeruginosa LecB is involved in pilus biogenesis and proteolytic activity. Moreover, neither lectin was involved in adhesion to human tracheobronchial mucin. We infer that some of the ascribed functions are secondary effects on other systems rather than effects of the lectins themselves.
摘要
铜绿假单胞菌表达两种凝集素，它们与黏附和生物膜形成有关。在本研究中，我们证明铜绿假单胞菌LecB参与菌毛生物合成和蛋白水解活性。此外，两种凝集素均不参与对人气管支气管黏蛋白的黏附。我们推断，一些所归因的功能是对其他系统的次要影响，而非凝集素本身的作用。
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6
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