格列本脲，一种钾离子（ATP）通道阻滞剂，在实验性小鼠皮肤利什曼病中显示出抗利什曼原虫活性。
Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis.
作者信息
Serrano-Martín Xenón, Payares Gilberto, Mendoza-León Alexis
机构信息
Laboratorio de Bioquímica y Biología Molecular de Parásitos, Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47577, Caracas 1041A, Venezuela.
出版信息
Antimicrob Agents Chemother. 2006 Dec;50(12):4214-6. doi: 10.1128/AAC.00617-06. Epub 2006 Oct 2.
Abstract
Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania (Leishmania) mexicana, the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.
摘要
格列本脲降低了感染墨西哥利什曼原虫（利什曼原虫属）的BALB/c小鼠的病变生长速率，其效果呈剂量依赖性，且最高剂量比葡甲胺更有效。在感染了格列本脲耐药株的动物中发现了对葡甲胺的交叉耐药性，但联合治疗即使在格列本脲耐药株中也能减少病变进展。
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