利什曼病：临床用药、耐药性及新进展
Leishmaniasis: drugs in the clinic, resistance and new developments.
作者信息
Ouellette Marc, Drummelsmith Jolyne, Papadopoulou Barbara
机构信息
Centre de Recherche en Infectiologie du Centre de Recherche du CHUL and Division de Microbiologie, Faculté de Médecine, Université Laval, Que., Canada G1V 4G2.
出版信息
Drug Resist Updat. 2004 Aug-Oct;7(4-5):257-66. doi: 10.1016/j.drup.2004.07.002.
The control of Leishmania infections relies primarily on chemotherapy. The arsenal of drugs available for treating Leishmania infections is limited and includes pentavalent antimonials, pentamidine, amphotericin B, miltefosine, fluconazole and few other drugs at various stages of their development process. In this review, we will discuss the latest results regarding resistance mechanisms to drugs used in the clinic against Leishmania infections.
利什曼原虫感染的控制主要依赖化疗。可用于治疗利什曼原虫感染的药物种类有限，包括五价锑剂、喷他脒、两性霉素B、米替福新、氟康唑以及其他几种处于不同研发阶段的药物。在本综述中，我们将讨论关于临床用于治疗利什曼原虫感染的药物耐药机制的最新研究结果。
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