从开口箭根茎的细胞毒性提取物中分离得到的一对非对映异构甾体皂苷。

A pair of diastereoisomeric steroidal saponins from cytotoxic extracts of Tupistra chinensis rhizomes.

作者信息

Zou Kun, Wang Junzhi, Du Ming, Li Qing, Tu Guangzhong

机构信息

Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang, PR China.

出版信息

Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1440-2. doi: 10.1248/cpb.54.1440.

DOI:10.1248/cpb.54.1440

PMID:17015986

Abstract

A pair of diastereoisomeric steroidal saponins were obtained from the saponin fraction (SF) of methanol extracts from Tupistra chinensis rhizomes, collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. The sample SF displayed marked inhibitory action in vitro towards HeLa and HL-60 cancer cell lines at 10 microg/ml by MTT method.

摘要

从采自中国神农架林区的开口箭根茎甲醇提取物的皂苷部分（SF）中获得了一对非对映异构甾体皂苷。基于化学和光谱证据，确定了它们的结构，如图1所示。通过MTT法，样品SF在10微克/毫升时对HeLa和HL-60癌细胞系显示出明显的体外抑制作用。