玉竹中具有细胞毒性的甾体皂苷

Cytotoxic steroidal saponins from Polygonatum zanlanscianense.

作者信息

Jin Jian-Ming, Zhang Ying-Jun, Li Hai-Zhou, Yang Chong-Ren

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2004 Dec;67(12):1992-5. doi: 10.1021/np049897u.

DOI:10.1021/np049897u

PMID:15620239

Abstract

Four new steroidal saponins, polygonatosides A-D (1-4), were isolated from the rhizomes of Polygonatum zanlanscianense, together with six known spirostanols (5-10) and a known megastigmane glycoside (11). Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1-11 against HeLa cells are described.

摘要

从滇黄精的根茎中分离得到了4个新的甾体皂苷，即黄精苷A-D（1-4），同时还得到了6个已知的螺旋甾烷醇（5-10）和1个已知的巨大戟烷糖苷（11）。基于光谱分析以及酸水解和酶水解的结果阐明了它们的结构。描述了化合物1-11对人宫颈癌HeLa细胞的细胞毒活性。