从开口箭根茎中提取的具有抑制一氧化氮生成作用的新型多羟基呋甾烷醇皂苷。
New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes.
作者信息
Xu Lan-Lan, Zou Kun, Wang Jun-Zhi, Wu Jun, Zhou Yuan, Dan Fei-Jun, Yang Jing
机构信息
Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China.
出版信息
Molecules. 2007 Aug 23;12(8):2029-37. doi: 10.3390/12082029.
Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.
从开口箭的根茎中获得了两种呋甾烷醇皂苷。基于化学和光谱证据，确定它们的结构分别为5β-呋甾-Δ(25(27))-烯-1β,2β,3β,4β,5β,7α,22ξ,26-八醇-6-酮-26-O-β-D-吡喃葡萄糖苷（1）和5β-呋甾-Δ(25(27))-烯-1β,2β,3β,4β,5β,6β,7α,22ξ,26-九醇-26-O-β-D-吡喃葡萄糖苷（2）。两种化合物在40μg/mL浓度下对脂多糖（LPS）诱导的大鼠腹腔巨噬细胞中NO的产生均表现出显著的抑制作用。
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