Bhambhani S, Kashyap V, Das D K
Division of Cytopathology, Indian Council of Medical Research, Maulana Azad Medical College, New Delhi.
Acta Cytol. 1990 Nov-Dec;34(6):809-12.
Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details. In the present study air-dried thyroid aspirates stained with the widely used May-Grünwald-Giemsa stain were evaluated. Nuclear grooves were observed in 88% of the May-Grünwald-Giemsa-stained aspirates from papillary thyroid carcinoma, usually in substantial numbers. A few grooved nuclei were seen in a small percentage of the other thyroid aspirates studied. These results show that nuclear grooves can also be used as a possible marker of papillary carcinoma of the thyroid in May-Grünwald-Giemsa-stained aspirates.
近期报告表明，核沟（裂隙或切迹）可作为细针穿刺抽吸物中甲状腺乳头状癌诊断的一项附加标准；这些研究大多在经巴氏染色或苏木精-伊红染色的酒精固定材料上进行，能清晰显示细胞核细节。在本研究中，对用广泛使用的美蓝-伊红染色的风干甲状腺抽吸物进行了评估。在88%的甲状腺乳头状癌美蓝-伊红染色抽吸物中观察到核沟，数量通常较多。在所研究的其他甲状腺抽吸物中，一小部分可见少数有核沟的细胞核。这些结果表明，在美蓝-伊红染色的抽吸物中，核沟也可作为甲状腺乳头状癌的一个可能标志物。
