Rupp M, Ehya H
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Acta Cytol. 1989 Jan-Feb;33(1):21-6.
Nuclear grooving has recently been shown to be a useful morphologic feature in the diagnosis of papillary carcinoma of the thyroid in tissue sections and imprint smears. In order to assess the diagnostic value of nuclear grooving in cytologic specimens, the presence of this feature was evaluated in fine needle aspirates from 20 papillary carcinomas of the thyroid, 10 follicular adenomas, 3 follicular carcinomas, 1 medullary carcinoma, 10 nodular goiters and 4 cases of Hashimoto's thyroiditis. In each case, 30 random high-power fields (HPFs), or all fields in less cellular smears, were examined, and the percentage of the fields in which nuclear grooving could be seen was recorded. Seventeen of 20 papillary carcinomas (85%) showed nuclear grooves in more than 25% of the HPFs examined; in the remaining three cases, grooves were observed in less than 25% of the HPFs. In control cases (all other thyroid lesions), nuclear grooves either were absent or were present in less than 25% of the HPFs examined. These findings suggest that nuclear grooving, when seen in abundance, can be considered a reliable criterion for the diagnosis of papillary carcinoma in fine needle aspiration cytology of the thyroid. The presence of occasional grooves, however, should be regarded as a nonspecific finding.
核沟最近已被证明是在组织切片和印片涂片中诊断甲状腺乳头状癌的一种有用的形态学特征。为了评估核沟在细胞学标本中的诊断价值，对20例甲状腺乳头状癌、10例滤泡性腺瘤、3例滤泡性癌、1例髓样癌、10例结节性甲状腺肿和4例桥本甲状腺炎的细针穿刺抽吸物中该特征的存在情况进行了评估。在每例病例中，检查30个随机高倍视野（HPF），或细胞涂片较少的所有视野，并记录可见核沟的视野百分比。20例甲状腺乳头状癌中有17例（85%）在超过25%的检查HPF中显示核沟；其余3例中，在不到25%的HPF中观察到核沟。在对照病例（所有其他甲状腺病变）中，核沟要么不存在，要么在不到25%的检查HPF中存在。这些发现表明，在甲状腺细针穿刺细胞学检查中，当大量出现核沟时，可被视为诊断乳头状癌的可靠标准。然而，偶尔出现核沟应被视为非特异性发现。
